Pathophysiology

Lack of adequate axon outgrowth & plasticity proteins coupled with i-NOS induced ionic Zn++ surge cause Neuroglia apoptosis and resultant disability

Injury to CNS neurons triggers glutamate release which intern activates NMDA receptors.
Calcium ion influx increases i-NOS activity dissociating ionic Zn++ from MT-ZN & increasing its concentration million folds.
Lack of growth stimulating/ trophic factors cause Neuroglia apoptosis and resultant disability.